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The majority of patients treated with immune checkpoint inhibitors such as monoclonal antibodies suffer from drug-induced immune-related adverse events (irAEs)

Treatment duration depends on the chosen method

Tumour growth delay ( T C ) was calculated by subtracting the median time to reach evaluation size (750 mg) of the treated group by the median time to evaluation size of the control group

doi: 10.1016/j.rbmo.2022.05.010 129 WangLTangJWangLTanFSongHZhouJet al

Oxytetracycline (Sigma-Aldrich) was added to the urine collection vessels of the metabolic cages to prevent bacterial deterioration

Then can reduce the dosage to 1 injection every 2 weeks for maintenance